On October 24, 2026, the first ministerial meeting was held in Istanbul, which saw the participation of the Foreign Ministers of Turkey, Egypt, Pakistan, and Saudi Arabia (the R4 group), together with their counterparts from France, Germany, Italy, and the United Kingdom. The event was officially announced by the Italian Ministry of Foreign Affairs and International Cooperation.

During the summit, the ministers discussed various issues of regional and international relevance. Central topics included the conflict between the United States/Israel and Iran, the Israeli-Palestinian crisis, with support for a two-state solution, and the Houthi militia attacks against Saudi Arabia and the government of Yemen.

Other important issues addressed were the security and freedom of navigation, as well as the escalation of tensions in the Straits of Hormuz, Bab el-Mandeb, and the Black Sea. The participants reiterated their commitment to continue diplomatic efforts aimed at promoting peace and stability in the region, managing security, economic, and commercial implications.

The ministers agreed on the urgent need to resolve regional conflicts through dialogue, diplomacy, and de-escalation of tensions, in accordance with United Nations resolutions. They finally decided to maintain this dialogue format to prevent further conflicts and strengthen peace and stability in the affected area.